The relationship between traffic-related air pollution exposures and allostatic load score among youth with type 1 diabetes in the SEARCH cohort

Jessica A Montresor-López; Stephanie R Reading; Jeffrey D Yanosky; Murray A Mittleman; Ronny A Bell; Tessa L Crume; Dana Dabelea; Lawrence Dolan; Ralph B D'Agostino Jr; Santica M Marcovina; Catherine Pihoker; Kristi Reynolds; Elaine Urbina; Angela D Liese; Lesliam Quirós-Alcalá; J Carson Smith; P Jacob Bueno de Mesquita; Robin C Puett

doi:10.1016/j.envres.2021.111075

The relationship between traffic-related air pollution exposures and allostatic load score among youth with type 1 diabetes in the SEARCH cohort

Environ Res. 2021 Jun:197:111075. doi: 10.1016/j.envres.2021.111075. Epub 2021 Mar 30.

Authors

Jessica A Montresor-López¹, Stephanie R Reading², Jeffrey D Yanosky³, Murray A Mittleman⁴, Ronny A Bell⁵, Tessa L Crume⁶, Dana Dabelea⁶, Lawrence Dolan⁷, Ralph B D'Agostino Jr⁸, Santica M Marcovina⁹, Catherine Pihoker¹⁰, Kristi Reynolds², Elaine Urbina¹¹, Angela D Liese¹², Lesliam Quirós-Alcalá¹³, J Carson Smith¹⁴, P Jacob Bueno de Mesquita¹, Robin C Puett¹⁵

Affiliations

¹ Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, 255 Valley Dr., Suite 2234, College Park, MD, 20742, USA.
² Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S Los Robles Ave #2, Pasadena, CA, 91101, USA.
³ Division of Epidemiology, Department of Public Health Sciences, Pennsylvania State University College of Medicine, 700 HMC Crescent Road, Hershey, PA, 17033, USA.
⁴ Department of Epidemiology, TH Chan Harvard School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
⁵ Department of Public Health, Brody School of Medicine, East Carolina University, 115 Heart Dr., Greenville, NC, 27834, USA.
⁶ Department of Epidemiology, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Center, 13001 E. 17th Place, Mail Stop B119, Fitzsimons Building, Room W3110, Aurora, CO, 80045, USA.
⁷ Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
⁸ Department of Biostatistical Sciences, Wake Forest University School of Medicine, 475 Vine Street, Winston-Salem, NC, 27101, USA.
⁹ Division of Metabolism, Endocrinology and Nutrition, Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Avenue North UW, Mailbox 359119, Seattle, WA, 98109, USA.
¹⁰ Department of Pediatrics, University of Washington, 4245 Roosevelt Way NE 4th Floor, Seattle, WA, 98105, USA.
¹¹ Heart Institute, Cincinnati Children's Hospital Medical Center, C4 Clinic, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
¹² Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Discovery 1 461, 915 Greene St, Columbia, SC, 29208, USA.
¹³ Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Room E6616, Baltimore, MD, 21205, USA.
¹⁴ Department of Kinesiology, School of Public Health, University of Maryland, 255 Valley Dr., Suite 2234, College Park, MD, 20742, USA.
¹⁵ Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, 255 Valley Dr., Suite 2234, College Park, MD, 20742, USA. Electronic address: rpuett@umd.edu.

Abstract

Objective: We investigated the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score, a marker of cumulative biological risk, among youth with type 1 diabetes.

Research design and methods: Participants were drawn from five clinical sites of the SEARCH for Diabetes in Youth (SEARCH) study (n = 2338). Baseline questionnaires, anthropometric measures, and a fasting blood test were taken at a clinic visit between 2001 and 2005. AL was operationalized using 10 biomarkers reflecting cardiovascular, metabolic, and inflammatory risk. Annual residential exposures to PM_2.5 and proximity to heavily-trafficked major roadways were estimated for each participant. Poisson regression models adjusted for sociodemographic and lifestyle factors were conducted for each exposure.

Results: No significant associations were observed between exposures to PM_2.5 or proximity to traffic and AL score, however analyses were suggestive of effect modification by race for residential distance to heavily-trafficked major roadways (p = 0.02). In stratified analyses, residing <100, 100-<200 and 200-<400 m compared to 400 m or more from heavily-trafficked major roadways was associated with 11%, 26% and 14% increases in AL score, respectively (95% CIs: -4, 29; 9, 45; -1, 30) for non-white participants compared to 6%, -2%, and -2% changes (95% CIs: -2, 15; -10, 7; -8, 6) for white participants.

Conclusions: Among this population of youth with type 1 diabetes, we did not observe consistent relationships between chronic exposures to particulate and traffic-related air pollution and changes in AL score, however associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.

Keywords: Air pollution; Allostatic load; Chronic exposure; Type 1 diabetes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adolescent
Air Pollutants* / analysis
Air Pollution* / adverse effects
Air Pollution* / analysis
Allostasis*
Diabetes Mellitus, Type 1* / chemically induced
Diabetes Mellitus, Type 1* / epidemiology
Environmental Exposure / analysis
Humans
Particulate Matter / analysis
Particulate Matter / toxicity
Traffic-Related Pollution*
Vehicle Emissions / analysis
Vehicle Emissions / toxicity

Substances

Air Pollutants
Particulate Matter
Vehicle Emissions

Abstract

Publication types

MeSH terms

Substances

Grants and funding