Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors

R Radhakrishnan; L G Presta; E F Meyer Jr; R Wildonger

doi:10.1016/0022-2836(87)90291-9

Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors

J Mol Biol. 1987 Dec 5;198(3):417-24. doi: 10.1016/0022-2836(87)90291-9.

Authors

R Radhakrishnan¹, L G Presta, E F Meyer Jr, R Wildonger

Affiliation

¹ Department of Biochemistry and Biophysics, Texas A & M University, College Station 77843.

PMID: 3430613
DOI: 10.1016/0022-2836(87)90291-9

Abstract

The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Benzoxazines
Carbamates*
Hydrogen Bonding
Models, Molecular
Oxazines*
Pancreas / enzymology*
Pancreatic Elastase*
Swine
X-Ray Diffraction

Substances

Benzoxazines
Carbamates
Oxazines
(1-(5-methyl-4-oxo-4H-3,1-benzoxazin-2-yl)-2-methylpropyl)carbamic acid 1,1-dimethylethyl ester
(1-(5-chloro-4-oxo-4H-3,1-benzoxazin-2-yl)-2-methylpropyl)carbamic acid 1,1-dimethylethyl ester
Pancreatic Elastase