Study objective: To study the progression of benign ovarian lesions to mucinous borderline ovarian tumors (mBOTs); analyze the clinicopathologic features, diagnosis, and management of mBOTs in pediatric and adolescent girls; and provide a review of the literature on mBOTs in this population.
Design: Retrospective chart review of female adolescents younger than 18 years diagnosed with mBOTs between July 2017 and February 2021.
Setting: Yale New Haven Hospital, New Haven, Connecticut; and Yale New Haven Health Bridgeport Hospital, Bridgeport, Connecticut.
Participants: Three female patients diagnosed with mBOTs between ages 12 and 17 years.
Interventions: None.
Main outcome measures: Clinical presentation, preoperative characteristics, surgical technique, histology, tumor stage, treatment, progression, outcome, and rate of recurrence.
Results: Three adolescent patients were identified to have mBOTs. All three patients presented with a chief complaint of abdominal pain. One of the 3 patients was premenarchal at presentation. Two of the 3 patients were initially diagnosed with a mucinous cystadenoma and had recurrences of an ovarian cyst in the same ovary within 5 and 17 months, respectively. Pathology of the recurrent cyst was consistent with mBOT. Two of the 3 patients initially underwent cystectomy, and all ultimately had a unilateral salpingo-oophorectomy. Subsequent surveillance over 2 to 4 years found no evidence of disease recurrence.
Conclusion: mBOTs are rare in the pediatric and adolescent population and could arise from benign ovarian tumors.
Keywords: Adolescent; Borderline ovarian tumor; KRAS; Mucinous borderline ovarian tumor; Mucinous cystadenoma; Pediatric; Tumor progression.
Copyright © 2021. Published by Elsevier Inc.