A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.
Keywords: antiviral; monkeypox; smallpox; tecovirimat.
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.