Long-Acting Injectable Therapy for People with HIV: Looking Ahead with Lessons from Psychiatry and Addiction Medicine

Gabriel G Edwards; Ayako Miyashita-Ochoa; Enrico G Castillo; David Goodman-Meza; Ippolytos Kalofonos; Raphael J Landovitz; Arleen A Leibowitz; Craig Pulsipher; Ed El Sayed; Steven Shoptaw; Chelsea L Shover; Michelle Tabajonda; Yvonne S Yang; Nina T Harawa

doi:10.1007/s10461-022-03817-z

Long-Acting Injectable Therapy for People with HIV: Looking Ahead with Lessons from Psychiatry and Addiction Medicine

AIDS Behav. 2023 Jan;27(1):10-24. doi: 10.1007/s10461-022-03817-z. Epub 2022 Sep 5.

Authors

Gabriel G Edwards^{1

2}, Ayako Miyashita-Ochoa³, Enrico G Castillo⁴, David Goodman-Meza⁵, Ippolytos Kalofonos^{6

7}, Raphael J Landovitz⁸, Arleen A Leibowitz³, Craig Pulsipher⁹, Ed El Sayed¹⁰, Steven Shoptaw^{6

11}, Chelsea L Shover¹², Michelle Tabajonda¹³, Yvonne S Yang^{7

14}, Nina T Harawa^{12

15}

Affiliations

¹ Division of General Internal Medicine & Health Services Research, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA. gedwards@mednet.ucla.edu.
² Division of General Internal Medicine & Health Services Research, David Geffen School of Medicine at UCLA, 1100 Glendon Ave., Suite 850, Los Angeles, CA, 90024, USA. gedwards@mednet.ucla.edu.
³ Department of Social Welfare, UCLA Luskin School of Public Affairs, Los Angeles, CA, USA.
⁴ Center for Social Medicine and Humanities in the Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
⁵ Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
⁶ Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
⁷ Greater Los Angeles Veterans Healthcare Administration, Los Angeles, CA, USA.
⁸ UCLA Center for Clinical AIDS Research & Education, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
⁹ Department of Government Affairs, APLA Health, Los Angeles, CA, USA.
¹⁰ Department of Pharmacology, Touro College of Medicine, New York, NY, USA.
¹¹ Department of Family Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
¹² Division of General Internal Medicine & Health Services Research, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
¹³ Department of Health Policy and Management, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
¹⁴ Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
¹⁵ Department of Psychiatry, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.

Abstract

Long-acting injectable antiretroviral medications are new to HIV treatment. People with HIV may benefit from a treatment option that better aligns with their preferences, but could also face new challenges and barriers. Authors from the fields of HIV, substance use treatment, and mental health collaborated on this commentary on the issues surrounding equitable implementation and uptake of LAI ART by drawing lessons from all three fields. We employ a socio-ecological framework beginning at the policy level and moving through the community, organizational, interpersonal, and patient levels. We look at extant literature on the topic as well as draw from the direct experience of our clinician-authors.

Keywords: Addiction medicine; Antiretroviral medication; Cost; HIV treatment; Implementation barriers and facilitators; Long acting injectable medication; Psychiatry.

MeSH terms

Addiction Medicine*
Anti-Retroviral Agents / therapeutic use
HIV Infections* / drug therapy
HIV Infections* / psychology
Humans
Mental Health
Psychiatry*

Substances

Anti-Retroviral Agents

Abstract

MeSH terms

Substances

Grants and funding