Appropriate Antibiotic Use for Group B Streptococcus Prophylaxis Among Penicillin-Allergic Patients in Academic and Nonacademic Hospitals

Beth L Pineles; Katherine E Goodman; Lisa Pineles; Anthony D Harris

doi:10.1093/ofid/ofac514

Appropriate Antibiotic Use for Group B Streptococcus Prophylaxis Among Penicillin-Allergic Patients in Academic and Nonacademic Hospitals

Open Forum Infect Dis. 2022 Oct 5;9(10):ofac514. doi: 10.1093/ofid/ofac514. eCollection 2022 Oct.

Authors

Beth L Pineles¹, Katherine E Goodman², Lisa Pineles², Anthony D Harris²

Affiliations

¹ Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
² Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

This study estimated prophylactic antibiotic usage rates for the prevention of early-onset invasive neonatal group B Streptococcus infection among patients with penicillin allergy. Undertreatment (no antibiotics, underuse of cefazolin, overuse of clindamycin inconsistent with resistance patterns) and overtreatment (vancomycin use) were common. Academic hospitals were marginally more adherent to guidelines than nonacademic hospitals.

Keywords: GBS; antibiotic; group B Streptococcus; penicillin allergy; pregnancy.