Background: Maximizing patient and allograft survival after liver transplant (LT) is important from both a patient care and organ utilization perspective. Although individual studies have addressed the effects of short-term post-LT complications on a limited scale, there has not been a systematic review of the literature formally assessing the potential effects of early complications on long-term outcomes.
Objectives: To identify whether short-term complications after LT affect allograft and overall survival, to identify short-term complications of particular clinical interest and significance, and to provide recommendations to improve post-LT graft and patient survival.
Data sources: Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.
Methods: A systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel.
Results: The literature review and analysis provided show that short-term complications have a large impact on allograft and patient survival after LT. The complications with the strongest effect on survival are acute kidney injury (AKI), biliary complications, and early allograft dysfunction (EAD).
Conclusion: This panel recommends taking measures to reduce the risk and incidence of short-term complications post-LT. Clinicians should pay particular attention to preventing or ameliorating AKI, biliary complications, and EAD (Quality of evidence; Moderate | Grade of Recommendation; Strong).
Keywords: allograft survival; complications; liver transplantation; morbidity; patient survival; recipient survival; short-term outcomes.
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.