Fast network oscillations during non-REM sleep support memory consolidation

Abstract

The neocortex is disconnected from the outside world during sleep, which has been hypothesized to be relevant for synaptic reorganization involved in memory consolidation. Fast network oscillations, such as hippocampal sharp-wave ripples, cortical ripples, and amygdalar high-frequency oscillations, are prominent during non-REM sleep. Although these oscillations are thought to be generated by local circuit mechanisms, their occurrence rates and amplitudes are modulated by thalamocortical spindles and neocortical slow oscillations during non-REM sleep, suggesting that fast network oscillations and slower oscillations cooperatively work to facilitate memory consolidation. This review discusses the recent progress in understanding the generation, coordination, and functional roles of fast network oscillations. Further, it outlines how fast network oscillations in distinct brain regions synergistically support memory consolidation and retrieval by hosting cross-regional coactivation of memory-related neuronal ensembles.

Keywords: Amygdalar high-frequency oscillations; Cortical ripples; Fast network oscillations; Hippocampal sharp-wave ripples; Memory consolidation; Non-REM sleep; Replay.