Isavuconazole in the Treatment of Chronic Forms of Coccidioidomycosis

Arash Heidari; Rupam Sharma; Qusai Shakir; Madiha Shah; Josh Clement; Monica A Donnelley; Trina Reynolds; Kate Trigg; Jeff Jolliff; Rasha Kuran; Royce Johnson; George R Thompson

doi:10.1093/cid/ciad146

Isavuconazole in the Treatment of Chronic Forms of Coccidioidomycosis

Clin Infect Dis. 2023 Jun 16;76(12):2196-2199. doi: 10.1093/cid/ciad146.

Authors

Arash Heidari^{1

2

3}, Rupam Sharma^{2

3}, Qusai Shakir², Madiha Shah⁴, Josh Clement⁴, Monica A Donnelley⁴, Trina Reynolds⁵, Kate Trigg⁵, Jeff Jolliff^{1

2}, Rasha Kuran^{1

2

3}, Royce Johnson^{1

2

3}, George R Thompson^{5

6}

Affiliations

¹ Department of Medicine, Division of Infectious Diseases, Kern Medical Center-University of California-Los Angeles, Bakersfield, California, USA.
² Valley Fever Institute, Bakersfield, California, USA.
³ Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
⁴ Department of Pharmacy, University of California-Davis Medical Center, Sacramento, California, USA.
⁵ Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Medical Center, Sacramento, California, USA.
⁶ Department of Medical Microbiology and Immunology, University of California-Davis, Davis, California, USA.

Abstract

Coccidioidomycosis is a fungal infection with a range of clinical manifestations. Currently used antifungal agents exhibit variable efficacy and toxicity profiles that necessitate evaluation of additional therapeutic options. Improvement was observed in the majority of patients treated with isavuconazole, with clinical failures observed only in those with coccidioidal meningitis.

Keywords: Coccidioides; Valley fever; antifungal; isavuconazonium; treatment.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / therapeutic use
Coccidioides
Coccidioidomycosis* / drug therapy
Coccidioidomycosis* / microbiology
Humans
Triazoles / therapeutic use

Substances

isavuconazole
Triazoles
Antifungal Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding