Previous SARS-CoV-2 Infection Is Not Associated With Increased Celiac Disease Autoimmunity in Children and Adolescents

Am J Gastroenterol. 2023 Sep 1;118(9):1698-1700. doi: 10.14309/ajg.0000000000002317. Epub 2023 Jun 9.

Abstract

Introduction: Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.

Methods: From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.

Results: Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95% confidence interval 0.63-1.59; P = 0.95).

Discussion: In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Autoantibodies
  • Autoimmunity
  • COVID-19*
  • Celiac Disease* / diagnosis
  • Child
  • Cross-Sectional Studies
  • Humans
  • SARS-CoV-2
  • Transglutaminases

Substances

  • Transglutaminases
  • Autoantibodies