Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

Tremor Other Hyperkinet Mov (N Y). 2023 Jun 12:13:21. doi: 10.5334/tohm.765. eCollection 2023.

Abstract

Background: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention.

Case report: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms.

Discussion: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.

Keywords: Hemiballismus; deep brain stimulation; hyperkinetic movement disorder.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Chorea* / diagnostic imaging
  • Chorea* / therapy
  • Deep Brain Stimulation*
  • Dyskinesias* / etiology
  • Dyskinesias* / therapy
  • Globus Pallidus / diagnostic imaging
  • Globus Pallidus / physiology
  • Humans
  • Movement Disorders* / therapy