Characterization of wound microbes in epidermolysis bullosa: A focus on Pseudomonas aeruginosa

Margaret E Scollan; Laura E Levin; Anne W Lucky; Kristen P Hook; Kathleen Peoples; Anna L Bruckner; James A Feinstein; Elena Pope; Catherine C McCuaig; Julie Powell; Lawrence F Eichenfield; Moise L Levy; Lucia Diaz; Sharon A Glick; Amy S Paller; John C Browning; Kimberly D Morel

doi:10.1111/pde.15383

Characterization of wound microbes in epidermolysis bullosa: A focus on Pseudomonas aeruginosa

Pediatr Dermatol. 2023 Sep-Oct;40(5):863-865. doi: 10.1111/pde.15383. Epub 2023 Jun 26.

Authors

Margaret E Scollan¹, Laura E Levin², Anne W Lucky³, Kristen P Hook⁴, Kathleen Peoples⁵, Anna L Bruckner⁶, James A Feinstein⁷, Elena Pope⁸, Catherine C McCuaig⁹, Julie Powell¹⁰, Lawrence F Eichenfield¹¹, Moise L Levy¹², Lucia Diaz¹³, Sharon A Glick¹⁴, Amy S Paller¹⁵, John C Browning¹⁶, Kimberly D Morel¹⁷

Affiliations

¹ Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
² Department of Dermatology, Columbia University Irving Medical Center, New York, New York, USA.
³ Departments of Pediatrics and Dermatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
⁴ Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
⁵ Children's Hospital Colorado, Aurora, Colorado, USA.
⁶ Departments of Dermatology and Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁷ Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁸ Section of Dermatology, Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
⁹ Departments of Pediatrics and Dermatology, CHU Sainte-Justine, University of Montreal, Montreal, Qubec, Canada.
¹⁰ Department of Dermatology, CHU Sainte- Justine, University of Montreal, Montreal, Qubec, Canada.
¹¹ Departments of Pediatrics and Dermatology, University of California San Diego, San Diego, California, USA.
¹² Departments of Pediatrics and Dermatology, Dell Children's Medical Center, Austin, Texas, USA.
¹³ Department of Dermatology, Dell Children's Medical Center, Austin, Texas, USA.
¹⁴ Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
¹⁵ Departments of Pediatrics and Dermatology, Northwestern University, Chicago, Illinois, USA.
¹⁶ Department of Dermatology, The Children's Hospital of San Antonio, San Antonio, Texas, USA.
¹⁷ Departments of Pediatrics and Dermatology, Columbia University Irving Medical Center, New York, New York, USA.

PMID: 37364926
PMCID: PMC10543531 (available on 2024-09-01)
DOI: 10.1111/pde.15383

Abstract

The most common bacteria isolated from wound cultures in patients recorded in the Epidermolysis Bullosa Clinical Characterization and Outcomes Database (EBCCOD) are Staphylococcus aureus and Pseudomonas aeruginosa. Given the prevalence of P. aeruginosa in this patient population and prior research implicating P. aeruginosa's potential role in carcinogenesis, we sought to further analyze patients with recorded wound cultures positive for Pseudomonas aeruginosa in the EBCCOD. We provide a descriptive analysis of this subset of patients and highlight potential avenues for future longitudinal studies that may have significant implications in our wound care management for patients with epidermolysis bullosa.

Keywords: epidermolysis bullosa; infection-bacterial; therapy-topical.

MeSH terms

Epidermolysis Bullosa* / complications
Epidermolysis Bullosa* / microbiology
Humans
Pseudomonas aeruginosa*

Abstract

MeSH terms

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