A new class of antiparasitic drugs

Science. 2023 Jun 30;380(6652):1320-1321. doi: 10.1126/science.adi5925. Epub 2023 Jun 29.

Abstract

Cyanotriazole compounds "poison" topoisomerase II of pathogenic trypanosomatids.

MeSH terms

  • Animals
  • Antiparasitic Agents* / classification
  • Antiparasitic Agents* / pharmacology
  • DNA Topoisomerases, Type II
  • Humans
  • Topoisomerase II Inhibitors* / classification
  • Topoisomerase II Inhibitors* / pharmacology
  • Triazoles* / classification
  • Triazoles* / pharmacology
  • Trypanosomatina* / drug effects

Substances

  • Antiparasitic Agents
  • DNA Topoisomerases, Type II
  • Triazoles
  • Topoisomerase II Inhibitors