Who Is at Risk for New Hepatitis B Infections Among People With HIV?

John M Sladic; Barbara S Taylor; Mae Thamer; Karen J Vigil; Onkar Kshirsagar; Anna Taranova; Andrew McCracken; Carmen G Sanchez; Mamta K Jain

doi:10.1093/ofid/ofad375

Who Is at Risk for New Hepatitis B Infections Among People With HIV?

Open Forum Infect Dis. 2023 Jul 17;10(8):ofad375. doi: 10.1093/ofid/ofad375. eCollection 2023 Aug.

Authors

John M Sladic¹, Barbara S Taylor¹, Mae Thamer², Karen J Vigil³, Onkar Kshirsagar², Anna Taranova¹, Andrew McCracken¹, Carmen G Sanchez⁴, Mamta K Jain^{5

6}

Affiliations

¹ University of Texas Health Science Center, San Antonio, Texas, USA.
² Medical Technology and Practice Patterns Institute, Bethesda, Maryland, USA.
³ University of Texas Health Science Center, Houston, Texas, USA.
⁴ University Health, San Antonio, Texas, USA.
⁵ UT Southwestern Medical Center, Dallas, Texas, USA.
⁶ Parkland Health, Dallas, Texas, USA.

Abstract

Hepatitis B virus (HBV) increases morbidity and mortality among people with HIV (PWH). We retrospectively analyzed HBV incidence among 5785 PWH. Fourteen had newly positive hepatitis B s antigen (mean 5.2 person-years of follow-up, 46.4/100 000 infections/year). These data show gaps in HBV vaccination and in the preventative efficacy of HBV-specific antiretroviral therapy.

Keywords: HBV; HBV vaccination; HIV; incident HBV infection.