To eat or not to eat: type 2 immunity controls food avoidance behavior

Albana L Kodra; Daniel Mucida

doi:10.1016/j.it.2023.07.007

To eat or not to eat: type 2 immunity controls food avoidance behavior

Trends Immunol. 2023 Sep;44(9):665-667. doi: 10.1016/j.it.2023.07.007. Epub 2023 Aug 15.

Authors

Albana L Kodra¹, Daniel Mucida²

Affiliations

¹ Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA. Electronic address: akodra@rockefeller.edu.
² Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. Electronic address: mucida@rockefeller.edu.

PMID: 37586904
DOI: 10.1016/j.it.2023.07.007

Abstract

Growing evidence suggests that food allergies are regulated by neuroimmune interactions. However, the underlying molecular mechanisms remain unclear. Plum et al. and Florsheim et al. identify IgE-mediated mast cell activation, leukotrienes, and growth differentiating factor 15 (GDF15) as key regulators of the avoidance response to food allergens in mice.

Keywords: allergy; food allergy; immunology; neuroimmune.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antigen Presentation*
Avoidance Learning*
Mice
Neuroimmunomodulation

Grants and funding

HHMI/Howard Hughes Medical Institute/United States