Male partners' support and influence on pregnant women's oral PrEP use and adherence in Malawi

Alinda M Young; Friday Saidi; Twambilile Phanga; Jennifer Tseka; Agatha Bula; Pearson Mmodzi; Lisa D Pearce; Suzanne Maman; Carol E Golin; Wilbroad Mutale; Benjamin H Chi; Lauren M Hill

doi:10.3389/frph.2023.1206075

Male partners' support and influence on pregnant women's oral PrEP use and adherence in Malawi

Front Reprod Health. 2023 Aug 8:5:1206075. doi: 10.3389/frph.2023.1206075. eCollection 2023.

Authors

Alinda M Young^{1

2}, Friday Saidi^{3

4}, Twambilile Phanga³, Jennifer Tseka³, Agatha Bula³, Pearson Mmodzi³, Lisa D Pearce⁵, Suzanne Maman⁶, Carol E Golin^{6

7}, Wilbroad Mutale⁸, Benjamin H Chi⁴, Lauren M Hill⁶

Affiliations

¹ Department of Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
² Women's Global Health Imperative at RTI International, Berkeley, CA, United States.
³ UNC Project-Malawi, Lilongwe, Malawi.
⁴ Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
⁵ Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
⁶ Department of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
⁷ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
⁸ Department of Health Policy, University of Zambia School of Public Health, Lusaka, Zambia.

Abstract

Introduction: Daily oral pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention method for pregnant and postpartum women, but adherence barriers exist. Understanding the role of male partners in supporting PrEP use may inform strategies to support PrEP adherence among pregnant and breastfeeding women.

Methods: To understand male partners' involvement in women's use of PrEP, we conducted in-depth interviews with pregnant women in Lilongwe, Malawi who had recently decided to use PrEP (n = 30) and their male partners (n = 20) in the context of a PrEP adherence trial. Women were purposively recruited to ensure variation in their partners' HIV status. Interviews were conducted in Chichewa using a semistructured guide. We followed a thematic approach to analyze the interview data.

Results: Most male partners were receptive to women using PrEP during pregnancy because it eased their fears of the woman and baby acquiring HIV. Men often played a key role in women's PrEP adherence by providing daily reminders and encouragement to adhere to their medication. The majority of women appreciated this support from the men as it lessened the burden of remembering to take their medications daily on their own and aided their adherence. However, several women who lacked male partner support spoke of wanting their partners to be more involved. Many men living with HIV found the mutual support beneficial for their antiretroviral therapy adherence, while men without HIV or with status unknown appreciated knowing that the family was protected. While most men were open to women continuing PrEP beyond the current study, some would only support it if women were still at risk for acquiring HIV.

Conclusion: In this study, male partners were strongly motivated to support the PrEP adherence of their female partners as a way of ensuring that the pregnant women and unborn babies were protected against HIV. Promoting disclosure and tangible support that arises organically among men may be helpful, but programs to enhance this support and identify ways to support women who do not receive support from their partners or do not wish to disclose their PrEP use to partners may be needed.

Keywords: HIV; Malawi; PrEP; male partners; pregnant and breastfeeding women; social support.

Abstract

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