Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

Yiwei Shen; Kamala Vanarsa; Zhihua Yin; Ting Zhang; Jessica Castillo; Min Dai; Linghua Zou; Ling Qin; Jieying Wang; Qiang Guo; Ramesh Saxena; Michelle Petri; Nan Shen; Zhizhong Ye; Chandra Mohan; Huihua Ding

doi:10.3389/fimmu.2023.1200167

Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity

Front Immunol. 2023 Aug 31:14:1200167. doi: 10.3389/fimmu.2023.1200167. eCollection 2023.

Authors

Yiwei Shen¹, Kamala Vanarsa², Zhihua Yin^{3

4}, Ting Zhang^{2

5}, Jessica Castillo², Min Dai¹, Linghua Zou^{3

6}, Ling Qin⁷, Jieying Wang⁸, Qiang Guo¹, Ramesh Saxena⁹, Michelle Petri¹⁰, Nan Shen^{1

3

11

12

13}, Zhizhong Ye^{3

4}, Chandra Mohan², Huihua Ding¹

Affiliations

¹ Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Biomedical Engineering, University of Houston, Houston, TX, United States.
³ Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
⁴ Department of Rheumatology, Joint Research Laboratory for Rheumatology of Shenzhen University Health Science Center and Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
⁵ Division of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
⁶ Department of Rehabilitation, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
⁷ Department of Nephrology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
⁸ Clinical Research Unit, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁹ Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
¹⁰ Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
¹¹ State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
¹² Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
¹³ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Abstract

Objective: There is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.

Methods: uL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and controls using ELISA. A longitudinal cohort includes 20 active Chinese LN patients.

Results: uL-selectin was significantly increased in active LN patients compared to active non-renal SLE, inactive LN, inactive non-renal SLE, chronic kidney disease patients, and healthy controls. uL-selectin positively correlated with global and renal disease activities as well as histological activity index and chronicity index (CI). Low uL-selectin was an independent predictor for high CI. During follow-up, uL-selectin levels decreased significantly in the complete renal remission group.

Conclusion: uL-selectin is a novel biomarker of disease activity and renal histopathology in LN across multiple ethnicities. It also reflects treatment response in LN patients during follow up.

Keywords: L-selectin; lupus nephritis; renal histopathology; treatment response; urinary biomarker.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Ethnicity
Humans
Kidney
L-Selectin
Lupus Nephritis* / diagnosis
Lupus Nephritis* / drug therapy
Renal Insufficiency, Chronic*

Substances

L-Selectin

Abstract

Publication types

MeSH terms

Substances

Grants and funding