Six undescribed lavandulylated flavonoids with PTP1B inhibition from the roots of Sophora flavescens

Abstract

Six undescribed lavandulylated flavonoids (1-6) were isolated from the roots of Sophora flavescens. Remarkably, compounds 1 and 2, which were composed of a flavane unit and a phloroglucinol unit, were the first reported dimers. Compounds 3 and 4 were the first reported neoflavonoids with lavandulyl units. Compounds 5 and 6 were chalcone with oxidized lavandulyl units. Their structures were fully characterized by cumulative analyses of UV, IR, HRESIMS, NMR and ECD spectroscopic data, along with computational calculations through density functional theory. Compounds 1 and 2 showed significant protein tyrosine phosphatase-1B inhibitory activities with IC₅₀ values of 2.669 and 3.596 μM, respectively.

Keywords: Dimers; Lavandulylated flavonoids; Leguminosae; PTP1B inhibitory activity; Sophora flavescens.