Secular Trends in Patent Ductus Arteriosus Management in Infants Born Preterm in the National Institute of Child Health and Human Development Neonatal Research Network

Dinushan C Kaluarachchi; Matthew A Rysavy; Benjamin A Carper; Valerie Y Chock; Matthew M Laughon; Carl H Backes; Tarah T Colaizy; Edward F Bell; Patrick J McNamara

doi:10.1016/j.jpeds.2023.113877

Secular Trends in Patent Ductus Arteriosus Management in Infants Born Preterm in the National Institute of Child Health and Human Development Neonatal Research Network

J Pediatr. 2024 Mar:266:113877. doi: 10.1016/j.jpeds.2023.113877. Epub 2023 Dec 20.

Authors

Dinushan C Kaluarachchi¹, Matthew A Rysavy², Benjamin A Carper³, Valerie Y Chock⁴, Matthew M Laughon⁵, Carl H Backes⁶, Tarah T Colaizy⁷, Edward F Bell⁷, Patrick J McNamara⁷

Affiliations

¹ Department of Pediatrics, University of Wisconsin-Madison, Madison, WI. Electronic address: kaluarachchi@pediatrics.wisc.edu.
² Department of Pediatrics, McGovern Medical School, UTHealth Houston, Houston, TX.
³ Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC.
⁴ Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA.
⁵ Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
⁶ Department of Pediatrics, Ohio State University and Nationwide Children's Hospital, Columbus, OH.
⁷ Department of Pediatrics, University of Iowa, Iowa City, IA.

PMID: 38135028
PMCID: PMC10922632 (available on 2025-03-01)
DOI: 10.1016/j.jpeds.2023.113877

Abstract

We evaluated changes in patent ductus arteriosus (PDA) diagnosis and treatment from 2012 through 2021 in a network of US academic hospitals. PDA treatment decreased among infants born at 26-28 weeks but not among infants born at 22-25 weeks. Rates of indomethacin use and PDA ligation decreased while acetaminophen use and transcatheter PDA closure increased.

Keywords: patent ductus arteriosus; preterm infant; secular trends.

MeSH terms

Child
Ductus Arteriosus, Patent* / surgery
Humans
Ibuprofen / therapeutic use
Indomethacin / therapeutic use
Infant
Infant, Newborn
Infant, Premature
National Institute of Child Health and Human Development (U.S.)
United States

Substances

Ibuprofen
Indomethacin

Abstract

MeSH terms

Substances

Grants and funding