Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice

Zachary R Zeisler; Kelsey A Heslin; Frederic M Stoll; Patrick R Hof; Roger L Clem; Peter H Rudebeck

doi:10.1101/2023.12.18.571711

Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice

bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.571711. doi: 10.1101/2023.12.18.571711.

Authors

Zachary R Zeisler^{1

2}, Kelsey A Heslin¹, Frederic M Stoll^{1

2}, Patrick R Hof¹, Roger L Clem¹, Peter H Rudebeck^{1

2}

Affiliations

¹ Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
² Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Abstract

The basolateral amygdala (BLA) projects to the frontal cortex (FC) in both rodents and primates, but the comparative organization of single-neuron BLA-FC projections is unknown. Using a barcoded connectomic approach, we found that BLA neurons are more likely to project to multiple distinct parts of FC in mice than in macaques. Further, while single BLA neuron projections to nucleus accumbens are similarly organized in mice and macaques, BLA-FC connections differ.

Keywords: Amygdala; comparative; connectomics; frontal cortex; human; macaque; mouse; neuroanatomy; projections.

Publication types

Preprint

Grants and funding

R34 NS122050/NS/NINDS NIH HHS/United States