A Case of Sustained Viral Shedding of Mpox With Ocular Involvement Resulting in Vision Loss

Lisa J Speiser; Alex M Wonnaparhown; Janis Blair; Ami Shah; Dharmendra R Patel; Ann E McCullough; Nelson Nicolasora; Ann M Khalsa; Robert Orenstein; Holenarasipur R Vikram; Vivian Huang; Maria Teresa Seville

doi:10.1093/ofid/ofad632

A Case of Sustained Viral Shedding of Mpox With Ocular Involvement Resulting in Vision Loss

Open Forum Infect Dis. 2023 Dec 14;11(1):ofad632. doi: 10.1093/ofid/ofad632. eCollection 2024 Jan.

Authors

Affiliations

¹ Department of Medicine, Division of Infectious Diseases, The Mayo Clinic Arizona, Phoenix, Arizona, USA.
² Department of Medicine, Division of Allergy and Immunology, The Mayo Clinic Arizona, Phoenix, Arizona, USA.
³ Department of Ophthalmology, The Mayo Clinic Arizona, Phoenix, Arizona, USA.
⁴ Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, The Mayo Clinic Arizona, Phoenix, Arizona, USA.
⁵ Department of Medicine, Banner University Medical Center, Phoenix, Arizona, USA.
⁶ Department of Family Medicine, Valleywise Health Medical Center, Phoenix, Arizona, USA.
⁷ Maricopa County Department of Public Health, Division of Epidemiology and Public Health Informatics, Phoenix, Arizona, USA.
⁸ Department of Medical Affairs, Novavax Inc., Gaithersburg, Maryland, USA.

Abstract

Mpox, caused by infection with Monkeypox virus, usually presents as a mild, self-limited illness in immunocompetent persons that resolves within 2-4 weeks. Serious complications have been reported when mpox lesions involve vulnerable anatomic sites, such as the eye, and in those with substantial immunosuppression. We describe a patient with advanced human immunodeficiency virus infection and sustained viral shedding of mpox with ocular involvement, which resulted in vision loss.

Keywords: HIV; MPOX; Ocular MPOX.

Publication types

Case Reports