New Strategies for Locally Advanced Breast Cancer: A Review of Inflammatory Breast Cancer and Nonresponders

Simran Malhotra; Audree B Tadros

doi:10.1016/j.clbc.2024.01.009

New Strategies for Locally Advanced Breast Cancer: A Review of Inflammatory Breast Cancer and Nonresponders

Clin Breast Cancer. 2024 Jan 21:S1526-8209(24)00009-0. doi: 10.1016/j.clbc.2024.01.009. Online ahead of print.

Authors

Simran Malhotra¹, Audree B Tadros²

Affiliations

¹ Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
² Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: tadrosa@mskcc.org.

PMID: 38431513
DOI: 10.1016/j.clbc.2024.01.009

Abstract

This review explores the new strategies around the management of locally advanced breast cancer (LABC), particularly for nonresponsive tumors and/or initially unresectable tumors at diagnosis, inclusive of inflammatory breast cancer. Nonresponders to neoadjuvant systemic therapy present a unique clinical challenge. Emerging medical therapeutics as well as considerations for use of radiotherapy and/or surgery in this setting are discussed. Specifically, the use of neoadjuvant radiotherapy for LABC and lymphedema prevention with lymphatic reconstruction following axillary lymph node dissection are reviewed.

Keywords: Breast cancer-related lymphedema; Breast surgery; Lymphatic reconstruction; Neoadjuvant systemic therapy; Radiotherapy.

Publication types

Review