Systems vaccinology studies - achievements and future potential

Jamie A Sugrue; Darragh Duffy

doi:10.1016/j.micinf.2024.105318

Systems vaccinology studies - achievements and future potential

Microbes Infect. 2024 Mar 7:105318. doi: 10.1016/j.micinf.2024.105318. Online ahead of print.

Authors

Jamie A Sugrue¹, Darragh Duffy²

Affiliations

¹ Translational Immunology Unit, Institut Pasteur, Université de Paris Cité, F75015, Paris, France.
² Translational Immunology Unit, Institut Pasteur, Université de Paris Cité, F75015, Paris, France. Electronic address: darragh.duffy@pasteur.fr.

PMID: 38460935
DOI: 10.1016/j.micinf.2024.105318

Abstract

Human immune responses to vaccination are variable both within and between populations. Systems vaccinology, which is the application of multi-omics technologies to vaccine studies, seeks to understand such variation and predict responses to optimise vaccine strategies. Here, we outline new approaches to systems vaccinology, focusing on the incorporation of additional cohorts, endpoints and technologies.

Keywords: Inter-individual variation; Sex differences; Systems immunology; Systems vaccinology.