Discrimination of benign, atypical, and malignant peripheral nerve sheath tumors in neurofibromatosis type 1 using diffusion-weighted MRI

Inka Ristow; Michael G Kaul; Maria Stark; Antonia Zapf; Christoph Riedel; Alexander Lenz; Victor F Mautner; Said Farschtschi; Ivayla Apostolova; Gerhard Adam; Peter Bannas; Johannes Salamon; Lennart Well

doi:10.1093/noajnl/vdae021

Discrimination of benign, atypical, and malignant peripheral nerve sheath tumors in neurofibromatosis type 1 using diffusion-weighted MRI

Neurooncol Adv. 2024 Feb 9;6(1):vdae021. doi: 10.1093/noajnl/vdae021. eCollection 2024 Jan-Dec.

Authors

Affiliations

¹ Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³ Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
⁴ Department of Diagnostic and Interventional Radiology, Medical Care Center Beste Trave, Bad Oldesloe, Germany.

Abstract

Background: Neurofibromatosis type 1 (NF1) is associated with the development of benign (BPNST) and malignant (MPNST) peripheral nerve sheath tumors. Recently described atypical neurofibromas (ANF) are considered pre-malignant precursor lesions to MPNSTs. Previous studies indicate that diffusion-weighted magnetic resonance imaging (DW-MRI) can reliably discriminate MPNSTs from BPNSTs. We therefore investigated the diagnostic accuracy of DW-MRI for the discrimination of benign, atypical, and malignant peripheral nerve sheath tumors.

Methods: In this prospective explorative single-center phase II diagnostic study, 44 NF1 patients (23 male; 30.1 ± 11.8 years) underwent DW-MRI (b-values 0-800 s/mm²) at 3T. Two radiologists independently assessed mean and minimum apparent diffusion coefficients (ADC_mean/min) in areas of largest tumor diameters and ADC_dark in areas of lowest signal intensity by manual contouring of the tumor margins of 60 BPNSTs, 13 ANFs, and 21 MPNSTs. Follow-up of ≥ 24 months (BPNSTs) or histopathological evaluation (ANFs + MPNSTs) served as diagnostic reference standard. Diagnostic ADC-based cut-off values for discrimination of the three tumor groups were chosen to yield the highest possible specificity while maintaining a clinically acceptable sensitivity.

Results: ADC values of pre-malignant ANFs clustered between BPNSTs and MPNSTs. Best BPNST vs. ANF + MPNST discrimination was obtained using ADC_dark at a cut-off value of 1.6 × 10^-3 mm²/s (85.3% sensitivity, 93.3% specificity), corresponding to an AUC of 94.3% (95% confidence interval: 85.2-98.0). Regarding BPNST + ANF vs. MPNST, best discrimination was obtained using an ADC_dark cut-off value of 1.4 × 10^-3 mm²/s (83.3% sensitivity, 94.5% specificity).

Conclusions: DW-MRI using ADC_dark allows specific and noninvasive discrimination of benign, atypical, and malignant nerve sheath tumors in NF1.

Keywords: DWI; MRI; apparent diffusion coefficient; malignant peripheral nerve sheath tumor; neurofibromatosis type 1.