Myocardial Matrix Hydrogels Mitigate Negative Remodeling and Improve Function in Right Heart Failure Model

Jervaughn D Hunter; Joshua M Mesfin; Tanzeel Ahmed; Alexander Chen; Kate Reimold; Arielle Hancko; Rebecca L Braden; Michael E Davis; Karen L Christman

doi:10.1016/j.jacbts.2024.01.006

Myocardial Matrix Hydrogels Mitigate Negative Remodeling and Improve Function in Right Heart Failure Model

JACC Basic Transl Sci. 2024 Mar 6;9(3):322-338. doi: 10.1016/j.jacbts.2024.01.006. eCollection 2024 Mar.

Authors

Jervaughn D Hunter¹, Joshua M Mesfin¹, Tanzeel Ahmed¹, Alexander Chen¹, Kate Reimold¹, Arielle Hancko¹, Rebecca L Braden¹, Michael E Davis², Karen L Christman¹

Affiliations

¹ Shu Chien-Gene Lay Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California-San Diego, San Diego, California, USA.
² Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.

Abstract

This study evaluates the effectiveness of myocardial matrix (MM) hydrogels in mitigating negative right ventricular (RV) remodeling in a rat model of RV heart failure. The goal was to assess whether a hydrogel derived from either the right or left ventricle could promote cardiac repair. Injured rat right ventricles were injected with either RV-or left ventricular-derived MM hydrogels. Both hydrogels improved RV function and morphology and reduced negative remodeling. This study supports the potential of injectable biomaterial therapies for treating RV heart failure.

Keywords: biomaterial; extracellular matrix; hydrogel; negative right ventricular remodeling; right ventricle.

Grants and funding

R01 HL146147/HL/NHLBI NIH HHS/United States