Management of Oligometastatic and Locally Recurrent Urothelial Carcinoma

Abstract

Purpose of review: To summarize and evaluate the literature on treatment approaches for oligometastatic and locally recurrent urothelial cancer.

Recent findings: There is no clear definition for oligometastatic urothelial cancers due to limited data. Studies focusing on oligometastatic and locally recurrent urothelial cancer have been primarily retrospective. Treatment options include local therapy with surgery or radiation, and generalized systemic therapy such as chemotherapy or immunotherapy. Oligometastatic and locally recurrent urothelial cancers remain challenging to manage, and treatment requires an interdisciplinary approach. Systemic therapy is nearly always a component of current care in the form of chemotherapy, but the role of immunotherapy has not been explored. Consideration of surgical and radiation options may improve outcomes, and no studies have compared directly between the two localized treatment options. The development of new prognostic and predictive biomarkers may also enhance the treatment landscape in the future.

Keywords: Bladder cancer; Locally recurrent disease; Oligometastatic disease; Urothelial carcinoma.