Chrysanthemum morifolium as a traditional herb: A review of historical development, classification, phytochemistry, pharmacology and application

Yuchen Liu; Chenfei Lu; Jing Zhou; Fenfen Zhou; Aijun Gui; Hongli Chu; Qingsong Shao

doi:10.1016/j.jep.2024.118198

Chrysanthemum morifolium as a traditional herb: A review of historical development, classification, phytochemistry, pharmacology and application

J Ethnopharmacol. 2024 Apr 14:330:118198. doi: 10.1016/j.jep.2024.118198. Online ahead of print.

Authors

Yuchen Liu¹, Chenfei Lu², Jing Zhou³, Fenfen Zhou⁴, Aijun Gui³, Hongli Chu³, Qingsong Shao⁵

Affiliations

¹ State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China; Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Hangzhou, 311300, China; College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China.
² State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China; Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Hangzhou, 311300, China; College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China. Electronic address: luchenfei0716@163.com.
³ College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China.
⁴ College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China; Wenzhou Forestry Extension and Wildlife Conservation Station, Wenzhou, 325027, China.
⁵ State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China; Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Hangzhou, 311300, China; College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, China. Electronic address: sqszjfc@126.com.

PMID: 38621465
DOI: 10.1016/j.jep.2024.118198

Abstract

Ethnopharmacological relevance: In recent years, Chinese herbal medicine has gained more and more recognition in disease prevention and control due to its low toxicity and comprehensive treatment. C. morifolium (Chrysanthemum morifolium Ramat.), as the medicine food homology plant with the bioactivity of anti-oxidation, anti-inflammatory, neuroprotection and cardiovascular protection, has important therapeutic effects and health benefits for colds, inflammation, cardiovascular diseases and various chronic diseases.

Aim of the study: By reviewing the historical development, classification and distribution of germplasm resources, phytochemistry, pharmacology, and modern application of C. morifolium, the paper provides a reliable basis for the further research and application of chrysanthemum as therapeutic agents and functional additives.

Materials and methods: The literature and information about C. morifolium published in the last ten years were collected from various platforms, including Google Scholar, PubMed, ScienceDirect, Web of Science and China Knowledge Network.

Results: A comprehensive analysis confirmed that C. morifolium originated in China, and it went through the development process from food and tea to medicine for more than 3000 years. During this period, different cultivars emerged through several breeding techniques and were distributed throughout the world. Moreover, A variety of chemical components such as flavonoids, phenolic acids, volatile oils, and terpenes in chrysanthemum have been proven they possess various pharmacology of anti-inflammatory, anti-oxidant, and prevention of chronic diseases by regulating inflammatory cytokines, oxidative stress responses and signaling pathways, which are the essential conditions to play a role in TCM, nutraceuticals and diet.

Conclusion: This paper provides a comprehensive review of historical development, classification, phytochemistry, pharmacology, and modern application of C. morifolium. However, future studies should continue to focus on the bioactive compounds and the synergistic mechanism of the "multi-component, multi-target, and multi-pathway" of chrysanthemum, and it is necessary to develop more innovative products with therapeutic effects.

Keywords: Application; C. morifolium; Classification; Historical development; Pharmacology; Phytochemistry.

Publication types

Review