Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib

Clin Transl Med. 2024 Apr;14(4):e1662. doi: 10.1002/ctm2.1662.

Authors

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
² Department of Urology, University of Arizona, Tucson, Arizona, USA.
³ Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
⁴ Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA.
⁵ Arizona Center for Drug Discovery, University of Arizona, Tucson, Arizona, USA.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Autophagy* / drug effects
Brain Neoplasms / drug therapy
Brain Neoplasms / pathology
Brain Neoplasms / secondary
Breast Neoplasms* / drug therapy
Breast Neoplasms* / pathology
Female
Humans
Lapatinib* / pharmacology
Lapatinib* / therapeutic use

Substances

Lapatinib
Antineoplastic Agents

Grants and funding