Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer

Anirudh Yalamanchali; Christopher Griffith; Chandana A Reddy; Shlomo A Koyfman; Neil M Woody; Shauna R Campbell; Natalie Silver; Joseph Scharpf; Robert R Lorenz; Brandon Prendes; Jamie A Ku; Eric Lamarre; Jessica L Geiger

doi:10.1002/hed.27782

Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer

Head Neck. 2024 Apr 25. doi: 10.1002/hed.27782. Online ahead of print.

Affiliations

¹ Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
² Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
³ Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁴ Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

PMID: 38660928
DOI: 10.1002/hed.27782

Abstract

Background: Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC).

Methods: From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease-free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable.

Results: A total of 113 patients were identified. Between major (>2 mm) versus minor ENE (≤2 mm), there was no significant difference in DFS (HR 1.18, 95%CI 0.72-1.92, p = 0.51) or OS (HR 1.17, 95%CI 0.70-1.96, p = 0.55). There was no significant association between ENE as a continuous variable and DFS (HR 0.97 per mm, 95%CI 0.87-1.4, p = 0.96) or OS (HR 0.96 per mm, 95%CI 0.83-1.11, p = 0.58).

Conclusion: No significant relationship was seen between ENE extent and DFS or OS in individuals with OCSCC.

Keywords: extranodal extension; oral cavity cancer; squamous cell carcinoma of head and neck.