Treatment Response Imaging in Prostate Cancer

Mina Swiha; Andrei Gafita; Andrew Nguyen; Louise Emmett

doi:10.1016/j.cpet.2024.03.009

Treatment Response Imaging in Prostate Cancer

PET Clin. 2024 Apr 25:S1556-8598(24)00024-5. doi: 10.1016/j.cpet.2024.03.009. Online ahead of print.

Authors

Mina Swiha¹, Andrei Gafita², Andrew Nguyen³, Louise Emmett⁴

Affiliations

¹ Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia; Nuclear Medicine Division, Department of Medical Imaging, University of Western Ontario, London, Canada. Electronic address: mina.swiha@gmail.com.
² Nuclear Medicine and Molecular Imaging Division, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, USA.
³ Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia.
⁴ Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, Australia; Garvan Institute of Medical Research, Sydney, Australia.

PMID: 38670877
DOI: 10.1016/j.cpet.2024.03.009

Abstract

Objective criteria for measuring treatment response in prostate cancer are critical to clinical research and practice. The Prostate Cancer Working Group 3 criteria are widely accepted relying only on conventional imaging for radiographic treatment response. Prostate-specific membrane antigen PET/computed tomography was proven to be superior to conventional imaging in initial diagnosis and biochemical recurrence of prostate cancer. Moreover, there is growing evidence of its role in treatment response assessment in prostate cancer. This study will review the different criteria for imaging treatment response on conventional and advanced molecular imaging for different therapies, and the future perspective in posttherapy imaging.

Keywords: (177)Lu-PSMA; PSMA-PET; PSMA-SPECT; Prostate cancer; Treatment response.

Publication types

Review