High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer

Front Endocrinol (Lausanne). 2024 Apr 16:15:1372753. doi: 10.3389/fendo.2024.1372753. eCollection 2024.

Abstract

Background: This study investigates the potential impact of high progesterone (P) level on the day following human chorionic gonadotropin (HCG) injection on the clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET).

Methods: Retrospective analysis was conducted on 6418 cycles of IVF-ET performed at Liuzhou Maternal and Child Health Hospital between August 2020 to December 2021. Excluding cycles with progesterone levels ≥1.5ng/ml on HCG injection, a total of 781 cycles were identified according to the standard, and they were divided into five groups according to the progesterone level on the day after HCG: Group A: progesterone level < 2.5 ng/ml (n = 128); Group B: 2.5 ng/ml ≤ progesterone level < 3.5 ng/ml (n = 174); Group C: 3.5 ng/ml ≤ progesterone level < 4.5 ng/ml (n = 153); Group D: 4.5 ng/ml ≤ progesterone level < 5.5 ng/ml (n = 132); Group E progesterone level ≥5.5 ng/ml(n=194). Comparative analyses of clinical data, including general clinical data, and clinical pregnancy outcomes such as clinical pregnancy rate, miscarriage rate, and live birth rate were performed among these groups.

Results: There were significant differences in estradiol levels on HCG injection, but there were no differences in available embryo rate, clinical pregnancy rate, miscarriage rate, and live birth rate. Binary logistic regression analysis showed that there was no significant correlation between P level on the day after HCG injection and the live birth rate.

Conclusion: Under the condition of low P level on HCG injection, high progesterone levels on the day after HCG injection does not affect the clinical pregnancy outcomes of IVF-ET.

Keywords: clinical pregnancy outcome; endometrial receptivity; human chorionic gonadotropin injection progesterone; in vitro fertilization-embryo transfer; progesterone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chorionic Gonadotropin* / administration & dosage
  • Embryo Transfer* / methods
  • Female
  • Fertilization in Vitro* / methods
  • Humans
  • Live Birth / epidemiology
  • Ovulation Induction / methods
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Rate*
  • Progesterone* / blood
  • Retrospective Studies

Substances

  • Progesterone
  • Chorionic Gonadotropin

Associated data

  • figshare/10.6084/m9.figshare.25019792

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Natural Science Foundation of China (82160296 to PH), Liuzhou Science and Technology Plan Project (2022CAC0115 to PH), Guangxi Clinical Research Center for Obstetrics and Gynecology (GuiKe AD22035223 to DZ), Fujian Province Joint Funds for the Innovation of Science and Technology (2023Y9232 to JW), The Plan Project of Fujian Province Science and Technology (2022J01778 to JW).