ABT-299, a potent antagonist of platelet activating factor

Adv Prostaglandin Thromboxane Leukot Res. 1995:23:475-7.
No abstract available

MeSH terms

  • Animals
  • Binding, Competitive
  • Blood Pressure / drug effects
  • Edema / prevention & control
  • Esterases / blood
  • Humans
  • Hypotension / chemically induced
  • Indoles / chemistry
  • Indoles / metabolism
  • Kinetics
  • Lipopolysaccharides / toxicity
  • Mice
  • Molecular Structure
  • Platelet Activating Factor / antagonists & inhibitors*
  • Platelet Activating Factor / metabolism
  • Platelet Activating Factor / pharmacology
  • Platelet Membrane Glycoproteins / antagonists & inhibitors
  • Platelet Membrane Glycoproteins / metabolism*
  • Prodrugs / chemistry
  • Prodrugs / metabolism
  • Prodrugs / pharmacology*
  • Pyridinium Compounds / chemistry
  • Pyridinium Compounds / metabolism
  • Pyridinium Compounds / pharmacology*
  • Rats
  • Receptors, Cell Surface*
  • Receptors, G-Protein-Coupled*
  • Shock, Septic / prevention & control
  • Thiazoles / chemistry
  • Thiazoles / metabolism
  • Thiazoles / pharmacology*

Substances

  • Indoles
  • Lipopolysaccharides
  • Platelet Activating Factor
  • Platelet Membrane Glycoproteins
  • Prodrugs
  • Pyridinium Compounds
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Thiazoles
  • platelet activating factor receptor
  • ABT 299
  • Esterases
  • A 85783.0