Abstract
Central administrations of neuropeptide Y and peptide YY (PYY) produce robust increases in food intake, and this response may be contingent upon the availability of insulin. In contrast, beta 2-adrenergic agonists decrease food intake, and this effect also appears to be dependent on circulating insulin. To investigate a possible interaction between PYY and beta 2-adrenergic function, rats were given systemic injections of terbutaline, a beta 2 agonist, at doses of 0, 5, 10, and 50 mg/kg prior to injections of 0.57 nmol PYY in the paraventricular nucleus of the hypothalamus. Terbutaline pretreatment significantly decreased feeding elicited by PYY in a dose-dependent fashion. This suggests that beta 2-adrenoreceptor activity is involved in PYY-induced feeding.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenergic beta-Agonists / pharmacology
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Animals
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Dose-Response Relationship, Drug
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Eating / drug effects
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Female
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Gastrointestinal Hormones / administration & dosage
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Gastrointestinal Hormones / antagonists & inhibitors*
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Gastrointestinal Hormones / pharmacology
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Hyperphagia / chemically induced
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Hyperphagia / prevention & control*
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Injections
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Paraventricular Hypothalamic Nucleus
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Peptide YY
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Peptides / administration & dosage
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Peptides / antagonists & inhibitors*
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Peptides / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Adrenergic, beta-2 / drug effects
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Receptors, Adrenergic, beta-2 / physiology
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Terbutaline / pharmacology*
Substances
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Adrenergic beta-Agonists
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Gastrointestinal Hormones
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Peptides
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Receptors, Adrenergic, beta-2
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Peptide YY
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Terbutaline