We review the physiopathology of Zenker diverticulum, its clinic manifestations, diagnosis and treatment, we present two cases registered and treated in the Hospital General de la Zona No. 1 "Gabriel Mancera" of the Mexican Institute of Social Security (IMSS), and compare with the results of other authors, emphasizing the utility of the Total Parenteral Nutrition (TPN) in pre and post operative period, to improve the nutritional condition and diminish the post-operative complications and hospital stancy.