A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys

D E Williams; J T Dunn; L S Park; E A Frieden; F R Seiler; A M Farese; T J Macvittie

A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys

Biotechnol Ther. 1993;4(1-2):17-29.

Authors

D E Williams¹, J T Dunn, L S Park, E A Frieden, F R Seiler, A M Farese, T J Macvittie

Affiliation

¹ Department of Experimental Hematology, Immunex Corporation, Seattle, Washington 98101.

PMID: 8374510

Abstract

The effects of a human GM-CSF/IL-3 fusion protein (PIXY321) were examined in a primate model of rebound hematopoiesis following sublethal irradiation. The results demonstrated an enhanced rate of both neutrophil and platelet regeneration, as well as functional activation of circulating neutrophils.

Publication types

Comparative Study

MeSH terms

Animals
Blood Platelets / cytology
Blood Platelets / drug effects*
Blood Platelets / radiation effects
Drug Stability
Enzyme-Linked Immunosorbent Assay
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacokinetics
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*
Hematopoiesis / drug effects*
Hydrogen Peroxide / metabolism
Interleukin-3 / pharmacokinetics
Interleukin-3 / pharmacology*
Macaca mulatta
Male
Neutrophils / cytology
Neutrophils / drug effects*
Neutrophils / metabolism
Neutrophils / radiation effects
Recombinant Fusion Proteins / pharmacokinetics
Recombinant Fusion Proteins / pharmacology*
Whole-Body Irradiation

Substances

Interleukin-3
PIXY321 fusion protein, recombinant
Recombinant Fusion Proteins
Granulocyte-Macrophage Colony-Stimulating Factor
Hydrogen Peroxide