Abstract
The experimental basis for use of 2-week semisynthetic penicillin plus aminoglycoside combination therapy for Staphylococcus aureus endocarditis is reviewed. The use of oral therapy is examined. Short-course combination of oral regimens can be effective and may be suitable for selected patients with S. aureus endocarditis.
MeSH terms
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Administration, Oral
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use
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Disease Models, Animal
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / therapeutic use*
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Endocarditis, Bacterial / drug therapy*
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Fluoroquinolones
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Humans
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Fluoroquinolones