Abstract
The role of granulocyte colony-stimulating factor with and without antibiotics in the treatment of catheter-related infection and infective endocarditis caused by methicillin-susceptible Staphylococcus aureus was assessed in the experimental rabbit model. Granulocyte colony-stimulating factor stimulated leukocytosis in infected animals but did not increase the clearance of methicillin-susceptible S. aureus from peripheral blood, subcutaneous port catheters, intravascular cardiac catheters, or aortic valve vegetations.
MeSH terms
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Animals
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Cardiac Catheterization
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Ceftriaxone / administration & dosage
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Ceftriaxone / therapeutic use*
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Cephalosporins / administration & dosage
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Cephalosporins / therapeutic use*
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Drug Combinations
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Granulocyte Colony-Stimulating Factor / therapeutic use*
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Leukocyte Count / drug effects
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Rabbits
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Survival Analysis
Substances
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Cephalosporins
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Drug Combinations
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Granulocyte Colony-Stimulating Factor
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Ceftriaxone