Abstract
The three-dimensional structure of Bcl-xL, an inhibitor of apoptosis, suggests how different combinations of proteins in the same family might be utilized to control apoptosis.
MeSH terms
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Amino Acid Sequence
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Animals
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Apoptosis / drug effects
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Apoptosis / physiology*
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Caspase 1
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Cysteine Endopeptidases / physiology
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DNA Damage
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Dimerization
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Humans
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Models, Molecular*
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / physiology
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Protein Conformation*
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Protein Multimerization
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Protein Structure, Tertiary
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Proto-Oncogene Proteins / chemistry*
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-bcl-2 / chemistry
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Proto-Oncogene Proteins c-bcl-2 / physiology
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Structure-Activity Relationship
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bcl-2-Associated X Protein
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bcl-X Protein
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fas Receptor / physiology
Substances
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BCL2L1 protein, human
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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bcl-2-Associated X Protein
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bcl-X Protein
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fas Receptor
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Cysteine Endopeptidases
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Caspase 1