Stopping death cold

Structure. 1996 Aug 15;4(8):879-83. doi: 10.1016/s0969-2126(96)00094-9.

Abstract

The three-dimensional structure of Bcl-xL, an inhibitor of apoptosis, suggests how different combinations of proteins in the same family might be utilized to control apoptosis.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Caspase 1
  • Cysteine Endopeptidases / physiology
  • DNA Damage
  • Dimerization
  • Humans
  • Models, Molecular*
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / physiology
  • Protein Conformation*
  • Protein Multimerization
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / chemistry*
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-bcl-2 / chemistry
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Structure-Activity Relationship
  • bcl-2-Associated X Protein
  • bcl-X Protein
  • fas Receptor / physiology

Substances

  • BCL2L1 protein, human
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2-Associated X Protein
  • bcl-X Protein
  • fas Receptor
  • Cysteine Endopeptidases
  • Caspase 1