Abstract
Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton. Activated RhoD causes rearrangements of the actin cytoskeleton and cell surface, and governs early endosome motility and distribution.
MeSH terms
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Actins / metabolism
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Amino Acid Sequence
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Animals
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Biological Transport
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Cell Line
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Cell Membrane / metabolism
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Cytoskeleton / metabolism
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Endosomes / metabolism*
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GTP Phosphohydrolases / metabolism*
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Humans
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Mice
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Microscopy, Video
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Molecular Sequence Data
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Mutation
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Proteins / metabolism*
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Receptors, Transferrin / metabolism
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Recombinant Proteins / metabolism
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rho GTP-Binding Proteins*
Substances
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Actins
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Proteins
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Receptors, Transferrin
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Recombinant Proteins
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RHOD protein, human
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Rhod protein, mouse
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GTP Phosphohydrolases
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rho GTP-Binding Proteins