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Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.
Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA. Mahalingam B, et al. J Immunol. 2011 Dec 15;187(12):6393-401. doi: 10.4049/jimmunol.1102394. Epub 2011 Nov 16. J Immunol. 2011. PMID: 22095715 Free PMC article.
Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.
Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA. Mahalingam B, et al. J Biol Chem. 2014 May 16;289(20):13801-9. doi: 10.1074/jbc.M113.546929. Epub 2014 Apr 1. J Biol Chem. 2014. PMID: 24692540 Free PMC article.
Integrin structure, allostery, and bidirectional signaling.
Arnaout MA, Mahalingam B, Xiong JP. Arnaout MA, et al. Among authors: mahalingam b. Annu Rev Cell Dev Biol. 2005;21:381-410. doi: 10.1146/annurev.cellbio.21.090704.151217. Annu Rev Cell Dev Biol. 2005. PMID: 16212500 Review.
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