Olejniczak ET - Search Results

1

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.

Liu G, Huth JR, Olejniczak ET, Mendoza R, DeVries P, Leitza S, Reilly EB, Okasinski GF, Fesik SW, von Geldern TW. Liu G, et al. Among authors: olejniczak et. J Med Chem. 2001 Apr 12;44(8):1202-10. doi: 10.1021/jm000503f. J Med Chem. 2001. PMID: 11312920

2

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML Jr, Wilson AE, Fesik SW, Staunton DE. Huth JR, et al. Among authors: olejniczak et. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5231-6. doi: 10.1073/pnas.97.10.5231. Proc Natl Acad Sci U S A. 2000. PMID: 10805782 Free PMC article.

3

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW. Oost TK, et al. Among authors: olejniczak et. J Med Chem. 2004 Aug 26;47(18):4417-26. doi: 10.1021/jm040037k. J Med Chem. 2004. PMID: 15317454

4

Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide.

Liu Z, Olejniczak ET, Fesik SW. Liu Z, et al. Among authors: olejniczak et. Protein Expr Purif. 2004 Oct;37(2):493-8. doi: 10.1016/j.pep.2004.06.036. Protein Expr Purif. 2004. PMID: 15358376

5

Non-peptidic small molecule inhibitors of XIAP.

Park CM, Sun C, Olejniczak ET, Wilson AE, Meadows RP, Betz SF, Elmore SW, Fesik SW. Park CM, et al. Among authors: olejniczak et. Bioorg Med Chem Lett. 2005 Feb 1;15(3):771-5. doi: 10.1016/j.bmcl.2004.11.010. Bioorg Med Chem Lett. 2005. PMID: 15664855

6

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.

Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET. Stewart KD, et al. Among authors: olejniczak et. Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. doi: 10.1016/j.bmcl.2009.11.076. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20004576

7

NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein.

Petros AM, Gemmecker G, Neri P, Olejniczak ET, Nettesheim D, Xu RX, Gubbins EG, Smith H, Fesik SW. Petros AM, et al. Among authors: olejniczak et. J Med Chem. 1992 Jun 26;35(13):2467-73. doi: 10.1021/jm00091a015. J Med Chem. 1992. PMID: 1377749

8

NMR methods for determining the structures of enzyme/inhibitor complexes as an aid in drug design.

Fesik SW, Zuiderweg ER, Olejniczak ET, Gampe RT Jr. Fesik SW, et al. Among authors: olejniczak et. Biochem Pharmacol. 1990 Jul 1;40(1):161-7. doi: 10.1016/0006-2952(90)90191-m. Biochem Pharmacol. 1990. PMID: 2115336 Review.

9

A computer-based protocol for semiautomated assignments and 3D structure determination of proteins.

Meadows RP, Olejniczak ET, Fesik SW. Meadows RP, et al. Among authors: olejniczak et. J Biomol NMR. 1994 Jan;4(1):79-96. doi: 10.1007/BF00178337. J Biomol NMR. 1994. PMID: 7510556

10

A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments.

Logan TM, Olejniczak ET, Xu RX, Fesik SW. Logan TM, et al. Among authors: olejniczak et. J Biomol NMR. 1993 Mar;3(2):225-31. doi: 10.1007/BF00178264. J Biomol NMR. 1993. PMID: 8477187

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