Meadows RP - Search Results

1

NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.

Hajduk PJ, Shuker SB, Nettesheim DG, Craig R, Augeri DJ, Betebenner D, Albert DH, Guo Y, Meadows RP, Xu L, Michaelides M, Davidsen SK, Fesik SW. Hajduk PJ, et al. Among authors: meadows rp. J Med Chem. 2002 Dec 19;45(26):5628-39. doi: 10.1021/jm020160g. J Med Chem. 2002. PMID: 12477346

2

Non-peptidic small molecule inhibitors of XIAP.

Park CM, Sun C, Olejniczak ET, Wilson AE, Meadows RP, Betz SF, Elmore SW, Fesik SW. Park CM, et al. Among authors: meadows rp. Bioorg Med Chem Lett. 2005 Feb 1;15(3):771-5. doi: 10.1016/j.bmcl.2004.11.010. Bioorg Med Chem Lett. 2005. PMID: 15664855

3

Discovering high-affinity ligands for proteins: SAR by NMR.

Shuker SB, Hajduk PJ, Meadows RP, Fesik SW. Shuker SB, et al. Among authors: meadows rp. Science. 1996 Nov 29;274(5292):1531-4. doi: 10.1126/science.274.5292.1531. Science. 1996. PMID: 8929414

4

NMR-based screening in drug discovery.

Hajduk PJ, Meadows RP, Fesik SW. Hajduk PJ, et al. Among authors: meadows rp. Q Rev Biophys. 1999 Aug;32(3):211-40. doi: 10.1017/s0033583500003528. Q Rev Biophys. 1999. PMID: 11194565 Review. No abstract available.

5

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW. Oost TK, et al. Among authors: meadows rp. J Med Chem. 2004 Aug 26;47(18):4417-26. doi: 10.1021/jm040037k. J Med Chem. 2004. PMID: 15317454

6

Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex.

Xu RX, Meadows RP, Fesik SW. Xu RX, et al. Among authors: meadows rp. Biochemistry. 1993 Mar 16;32(10):2473-80. doi: 10.1021/bi00061a004. Biochemistry. 1993. PMID: 7680570

7

Solution structure of a low molecular weight protein tyrosine phosphatase.

Logan TM, Zhou MM, Nettesheim DG, Meadows RP, Van Etten RL, Fesik SW. Logan TM, et al. Among authors: meadows rp. Biochemistry. 1994 Sep 20;33(37):11087-96. doi: 10.1021/bi00203a005. Biochemistry. 1994. PMID: 7727361

8

Solution structure of a pleckstrin-homology domain.

Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW. Yoon HS, et al. Among authors: meadows rp. Nature. 1994 Jun 23;369(6482):672-5. doi: 10.1038/369672a0. Nature. 1994. PMID: 8208296

9

Discovering high-affinity ligands for proteins.

Hajduk PJ, Meadows RP, Fesik SW. Hajduk PJ, et al. Among authors: meadows rp. Science. 1997 Oct 17;278(5337):497,499. doi: 10.1126/science.278.5337.497. Science. 1997. PMID: 9381145 No abstract available.

10

Accurate measurement of H(N)-H(alpha) residual dipolar couplings in proteins.

Cai M, Wang H, Olejniczak ET, Meadows RP, Gunasekera AH, Xu N, Fesik SW. Cai M, et al. Among authors: meadows rp. J Magn Reson. 1999 Aug;139(2):451-3. doi: 10.1006/jmre.1999.1819. J Magn Reson. 1999. PMID: 10423386

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