Nettesheim DG - Search Results

1

NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.

Hajduk PJ, Shuker SB, Nettesheim DG, Craig R, Augeri DJ, Betebenner D, Albert DH, Guo Y, Meadows RP, Xu L, Michaelides M, Davidsen SK, Fesik SW. Hajduk PJ, et al. Among authors: nettesheim dg. J Med Chem. 2002 Dec 19;45(26):5628-39. doi: 10.1021/jm020160g. J Med Chem. 2002. PMID: 12477346

2

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

Petros AM, Dinges J, Augeri DJ, Baumeister SA, Betebenner DA, Bures MG, Elmore SW, Hajduk PJ, Joseph MK, Landis SK, Nettesheim DG, Rosenberg SH, Shen W, Thomas S, Wang X, Zanze I, Zhang H, Fesik SW. Petros AM, et al. Among authors: nettesheim dg. J Med Chem. 2006 Jan 26;49(2):656-63. doi: 10.1021/jm0507532. J Med Chem. 2006. PMID: 16420051

3

Identification of novel inhibitors of urokinase via NMR-based screening.

Hajduk PJ, Boyd S, Nettesheim D, Nienaber V, Severin J, Smith R, Davidson D, Rockway T, Fesik SW. Hajduk PJ, et al. J Med Chem. 2000 Oct 19;43(21):3862-6. doi: 10.1021/jm0002228. J Med Chem. 2000. PMID: 11052791

4

Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.

Sheppard GS, Wang J, Kawai M, Fidanze SD, BaMaung NY, Erickson SA, Barnes DM, Tedrow JS, Kolaczkowski L, Vasudevan A, Park DC, Wang GT, Sanders WJ, Mantei RA, Palazzo F, Tucker-Garcia L, Lou P, Zhang Q, Park CH, Kim KH, Petros A, Olejniczak E, Nettesheim D, Hajduk P, Henkin J, Lesniewski R, Davidsen SK, Bell RL. Sheppard GS, et al. J Med Chem. 2006 Jun 29;49(13):3832-49. doi: 10.1021/jm0601001. J Med Chem. 2006. PMID: 16789740

5

Discovery of a novel small molecule binding site of human survivin.

Wendt MD, Sun C, Kunzer A, Sauer D, Sarris K, Hoff E, Yu L, Nettesheim DG, Chen J, Jin S, Comess KM, Fan Y, Anderson SN, Isaac B, Olejniczak ET, Hajduk PJ, Rosenberg SH, Elmore SW. Wendt MD, et al. Among authors: nettesheim dg. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3122-9. doi: 10.1016/j.bmcl.2007.03.042. Epub 2007 Mar 16. Bioorg Med Chem Lett. 2007. PMID: 17391963

6

Solution structure of a low molecular weight protein tyrosine phosphatase.

Logan TM, Zhou MM, Nettesheim DG, Meadows RP, Van Etten RL, Fesik SW. Logan TM, et al. Among authors: nettesheim dg. Biochemistry. 1994 Sep 20;33(37):11087-96. doi: 10.1021/bi00203a005. Biochemistry. 1994. PMID: 7727361

7

Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.

Wiedeman PE, Fesik SW, Petros AM, Nettesheim DG, Mollison KW, Lane BC, Or YS, Luly JR. Wiedeman PE, et al. Among authors: nettesheim dg. J Med Chem. 1999 Oct 21;42(21):4456-61. doi: 10.1021/jm980252z. J Med Chem. 1999. PMID: 10543889

8

NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein.

Petros AM, Gemmecker G, Neri P, Olejniczak ET, Nettesheim D, Xu RX, Gubbins EG, Smith H, Fesik SW. Petros AM, et al. J Med Chem. 1992 Jun 26;35(13):2467-73. doi: 10.1021/jm00091a015. J Med Chem. 1992. PMID: 1377749

9

Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR.

Meadows RP, Nettesheim DG, Xu RX, Olejniczak ET, Petros AM, Holzman TF, Severin J, Gubbins E, Smith H, Fesik SW. Meadows RP, et al. Among authors: nettesheim dg. Biochemistry. 1993 Jan 26;32(3):754-65. doi: 10.1021/bi00054a004. Biochemistry. 1993. PMID: 7678499

10

Solution structure of the ets domain of Fli-1 when bound to DNA.

Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW. Liang H, et al. Among authors: nettesheim dg. Nat Struct Biol. 1994 Dec;1(12):871-5. doi: 10.1038/nsb1294-871. Nat Struct Biol. 1994. PMID: 7773776

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