Randal M - Search Results

1

Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Wells J, et al. Among authors: randal m. Ernst Schering Res Found Workshop. 2003;(42):19-27. doi: 10.1007/978-3-662-05314-0_3. Ernst Schering Res Found Workshop. 2003. PMID: 12664533 No abstract available.

2

Binding of small molecules to an adaptive protein-protein interface.

Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Arkin MR, et al. Among authors: randal m. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. doi: 10.1073/pnas.252756299. Epub 2003 Feb 11. Proc Natl Acad Sci U S A. 2003. PMID: 12582206 Free PMC article.

3

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2.

Hyde J, Braisted AC, Randal M, Arkin MR. Hyde J, et al. Among authors: randal m. Biochemistry. 2003 Jun 3;42(21):6475-83. doi: 10.1021/bi034138g. Biochemistry. 2003. PMID: 12767230

4

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Raimundo BC, et al. Among authors: randal m. J Med Chem. 2004 Jun 3;47(12):3111-30. doi: 10.1021/jm049967u. J Med Chem. 2004. PMID: 15163192

5

Site-directed ligand discovery.

Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. Erlanson DA, et al. Among authors: randal m. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9367-72. doi: 10.1073/pnas.97.17.9367. Proc Natl Acad Sci U S A. 2000. PMID: 10944209 Free PMC article.

6

Potent small-molecule binding to a dynamic hot spot on IL-2.

Thanos CD, Randal M, Wells JA. Thanos CD, et al. Among authors: randal m. J Am Chem Soc. 2003 Dec 17;125(50):15280-1. doi: 10.1021/ja0382617. J Am Chem Soc. 2003. PMID: 14664558

7

Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.

Erlanson DA, McDowell RS, He MM, Randal M, Simmons RL, Kung J, Waight A, Hansen SK. Erlanson DA, et al. Among authors: randal m. J Am Chem Soc. 2003 May 14;125(19):5602-3. doi: 10.1021/ja034440c. J Am Chem Soc. 2003. PMID: 12733877

8

The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.

Randal M, Kossiakoff AA. Randal M, et al. Structure. 2001 Feb 7;9(2):155-63. doi: 10.1016/s0969-2126(01)00567-6. Structure. 2001. PMID: 11250200 Free article.

9

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Yang W, et al. Among authors: randal m. Biochemistry. 2009 Jun 2;48(21):4488-96. doi: 10.1021/bi900017q. Biochemistry. 2009. PMID: 19284778

10

Allosteric inhibition of protein tyrosine phosphatase 1B.

Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK. Wiesmann C, et al. Among authors: randal m. Nat Struct Mol Biol. 2004 Aug;11(8):730-7. doi: 10.1038/nsmb803. Epub 2004 Jul 18. Nat Struct Mol Biol. 2004. PMID: 15258570

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