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A strategy for high-throughput assay development using leads derived from nuclear magnetic resonance-based screening.
J Biomol Screen. 2002 Oct;7(5):429-32. doi: 10.1177/108705702237674.
J Biomol Screen. 2002.
PMID: 14599358
Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.
Towne DL, Nicholl EE, Comess KM, Galasinski SC, Hajduk PJ, Abraham VC.
Towne DL, et al.
J Biomol Screen. 2012 Sep;17(8):1005-17. doi: 10.1177/1087057112450050. Epub 2012 Jun 15.
J Biomol Screen. 2012.
PMID: 22706350
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Solution structure and function of a conserved protein SP14.3 encoded by an essential Streptococcus pneumoniae gene.
Yu L, Gunasekera AH, Mack J, Olejniczak ET, Chovan LE, Ruan X, Towne DL, Lerner CG, Fesik SW.
Yu L, et al. Among authors: towne dl.
J Mol Biol. 2001 Aug 17;311(3):593-604. doi: 10.1006/jmbi.2001.4894.
J Mol Biol. 2001.
PMID: 11493012
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Novel antibacterial class.
Dandliker PJ, Pratt SD, Nilius AM, Black-Schaefer C, Ruan X, Towne DL, Clark RF, Englund EE, Wagner R, Weitzberg M, Chovan LE, Hickman RK, Daly MM, Kakavas S, Zhong P, Cao Z, David CA, Xuei X, Lerner CG, Soni NB, Bui M, Shen LL, Cai Y, Merta PJ, Saiki AY, Beutel BA.
Dandliker PJ, et al. Among authors: towne dl.
Antimicrob Agents Chemother. 2003 Dec;47(12):3831-9. doi: 10.1128/AAC.47.12.3831-3839.2003.
Antimicrob Agents Chemother. 2003.
PMID: 14638491
Free PMC article.
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Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans.
Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ.
Abraham VC, et al. Among authors: towne dl.
J Biomol Screen. 2008 Jul;13(6):527-37. doi: 10.1177/1087057108318428. Epub 2008 Jun 19.
J Biomol Screen. 2008.
PMID: 18566484
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A high-throughput soft agar assay for identification of anticancer compound.
Anderson SN, Towne DL, Burns DJ, Warrior U.
Anderson SN, et al. Among authors: towne dl.
J Biomol Screen. 2007 Oct;12(7):938-45. doi: 10.1177/1087057107306130.
J Biomol Screen. 2007.
PMID: 17942786
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Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease.
Konstantinidis AK, Richardson PL, Kurtz KA, Tripathi R, Chen CM, Huang P, Randolph J, Towne D, Donnelly J, Warrior U, Middleton T, Kati WM.
Konstantinidis AK, et al.
Anal Biochem. 2007 Sep 15;368(2):156-67. doi: 10.1016/j.ab.2007.06.020. Epub 2007 Jun 17.
Anal Biochem. 2007.
PMID: 17644059
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Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark RF, Hansen TM, Longenecker KL, Raich D, Korepanova AV, Cepa S, Towne DL, Abraham VC, Tang H, Richardson PL, McLoughlin SM, Badagnani I, Curtin ML, Michaelides MR, Maag D, Buchanan FG, Chiang GG, Gao W, Rosenberg SH, Brenner C, Tse C.
Wilsbacher JL, et al. Among authors: towne dl.
Mol Cancer Ther. 2017 Jul;16(7):1236-1245. doi: 10.1158/1535-7163.MCT-16-0819. Epub 2017 May 3.
Mol Cancer Ther. 2017.
PMID: 28468779
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