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Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals.
Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Bethony J, et al. Among authors: plieskatt j. FASEB J. 2005 Oct;19(12):1743-5. doi: 10.1096/fj.05-3936fje. Epub 2005 Jul 21. FASEB J. 2005. PMID: 16037096
Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials.
Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Goud GN, et al. Among authors: plieskatt j. Vaccine. 2005 Sep 15;23(39):4754-64. doi: 10.1016/j.vaccine.2005.04.040. Vaccine. 2005. PMID: 16054275
Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.
Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Fujiwara RT, et al. Among authors: plieskatt j. Clin Vaccine Immunol. 2007 Mar;14(3):281-7. doi: 10.1128/CVI.00404-06. Epub 2007 Jan 31. Clin Vaccine Immunol. 2007. PMID: 17267592 Free PMC article.
An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.
Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. Pearson MS, et al. Among authors: plieskatt j. FASEB J. 2009 Sep;23(9):3007-19. doi: 10.1096/fj.09-131433. Epub 2009 Apr 20. FASEB J. 2009. PMID: 19380510 Free PMC article.
Potency testing for the experimental Na-GST-1 hookworm vaccine.
Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM. Jariwala AR, et al. Among authors: plieskatt jl. Expert Rev Vaccines. 2010 Oct;9(10):1219-30. doi: 10.1586/erv.10.107. Expert Rev Vaccines. 2010. PMID: 20923271 Review.
Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen.
Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME. Goud GN, et al. Among authors: plieskatt jl. Protein Expr Purif. 2012 Jun;83(2):145-51. doi: 10.1016/j.pep.2012.03.013. Epub 2012 Apr 4. Protein Expr Purif. 2012. PMID: 22503665
Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine.
Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM. Brelsford JB, et al. Among authors: plieskatt jl. PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005385. doi: 10.1371/journal.pntd.0005385. eCollection 2017 Feb. PLoS Negl Trop Dis. 2017. PMID: 28192438 Free PMC article.
48 results