Gilbert H - Search Results

1

Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB.

Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Segatori L, et al. Among authors: gilbert h. J Biol Chem. 2006 Feb 24;281(8):4911-9. doi: 10.1074/jbc.M505453200. Epub 2005 Nov 9. J Biol Chem. 2006. PMID: 16280324 Free article.

2

De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC.

Arredondo S, Segatori L, Gilbert HF, Georgiou G. Arredondo S, et al. J Biol Chem. 2008 Nov 14;283(46):31469-76. doi: 10.1074/jbc.M803346200. Epub 2008 Sep 9. J Biol Chem. 2008. PMID: 18782764 Free PMC article.

3

Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC.

Arredondo SA, Chen TF, Riggs AF, Gilbert HF, Georgiou G. Arredondo SA, et al. J Biol Chem. 2009 Sep 4;284(36):23972-9. doi: 10.1074/jbc.M109.010199. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581640 Free PMC article.

4

Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways.

Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Segatori L, et al. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10018-23. doi: 10.1073/pnas.0403003101. Epub 2004 Jun 25. Proc Natl Acad Sci U S A. 2004. PMID: 15220477 Free PMC article.

5

In vivo and in vitro function of the Escherichia coli periplasmic cysteine oxidoreductase DsbG.

Bessette PH, Cotto JJ, Gilbert HF, Georgiou G. Bessette PH, et al. Among authors: gilbert hf. J Biol Chem. 1999 Mar 19;274(12):7784-92. doi: 10.1074/jbc.274.12.7784. J Biol Chem. 1999. PMID: 10075670 Free article.

6

Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase.

Zhan X, Schwaller M, Gilbert HF, Georgiou G. Zhan X, et al. Among authors: gilbert hf. Biotechnol Prog. 1999 Nov-Dec;15(6):1033-8. doi: 10.1021/bp990083r. Biotechnol Prog. 1999. PMID: 10585186

7

Reduction-reoxidation cycles contribute to catalysis of disulfide isomerization by protein-disulfide isomerase.

Schwaller M, Wilkinson B, Gilbert HF. Schwaller M, et al. J Biol Chem. 2003 Feb 28;278(9):7154-9. doi: 10.1074/jbc.M211036200. Epub 2002 Dec 15. J Biol Chem. 2003. PMID: 12486139 Free article.

This led to the proposal that the second active site cysteine provides an escape mechanism, preventing PDI from becoming trapped with substrates that isomerize slowly (Walker, K. W., and Gilbert, H. F. (1997) J. Biol. Chem. 272, 8845-8848). Escape also reduces the s …

This led to the proposal that the second active site cysteine provides an escape mechanism, preventing PDI from becoming trapped with substr …

8

A structural disulfide of yeast protein-disulfide isomerase destabilizes the active site disulfide of the N-terminal thioredoxin domain.

Wilkinson B, Xiao R, Gilbert HF. Wilkinson B, et al. J Biol Chem. 2005 Mar 25;280(12):11483-7. doi: 10.1074/jbc.M414203200. Epub 2005 Jan 13. J Biol Chem. 2005. PMID: 15649885 Free article.

., Solovyov, A., Winther, J. R., Holmgren, A., Lundstrom-Ljung, J., and Gilbert, H. F. (2004) J. Biol. Chem. 279, 49780-49786) suggest that the internal cysteines exist as a disulfide in the endoplasmic reticulum of Saccharomyces cerevisiae. ...

., Solovyov, A., Winther, J. R., Holmgren, A., Lundstrom-Ljung, J., and Gilbert, H. F. (2004) J. Biol. Chem. 279, 49780-49786) …

9

A 21-kDa C-terminal fragment of protein-disulfide isomerase has isomerase, chaperone, and anti-chaperone activities.

Puig A, Primm TP, Surendran R, Lee JC, Ballard KD, Orkiszewski RS, Makarov V, Gilbert HF. Puig A, et al. Among authors: gilbert hf. J Biol Chem. 1997 Dec 26;272(52):32988-94. doi: 10.1074/jbc.272.52.32988. J Biol Chem. 1997. PMID: 9407079 Free article.

10

Catalysis of thiol/disulfide exchange. Glutaredoxin 1 and protein-disulfide isomerase use different mechanisms to enhance oxidase and reductase activities.

Xiao R, Lundström-Ljung J, Holmgren A, Gilbert HF. Xiao R, et al. J Biol Chem. 2005 Jun 3;280(22):21099-106. doi: 10.1074/jbc.M411476200. Epub 2005 Apr 6. J Biol Chem. 2005. PMID: 15814611 Free article.

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