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Page 1
Insulin sensitivity and clustering of coronary heart disease risk factors in young adults. The Northern Ireland Young Hearts Study.
Andersen LB, Boreham CA, Young IS, Davey Smith G, Gallagher AM, Murray L, McCarron P. Andersen LB, et al. Among authors: young is. Prev Med. 2006 Jan;42(1):73-7. doi: 10.1016/j.ypmed.2005.10.009. Epub 2005 Dec 5. Prev Med. 2006. PMID: 16330091
BACKGROUND: Coronary heart disease (CHD) is usually associated with "clustering" of risk factors. Insulin resistance may cause deleterious changes in several CHD risk factors and is of potential interest in the aetiology of clustered risk. We analyzed how glucose an …
BACKGROUND: Coronary heart disease (CHD) is usually associated with "clustering" of risk factors. Insulin resistance may cause delete …
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults.
Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS. Kluijtmans LA, et al. Among authors: young is. Blood. 2003 Apr 1;101(7):2483-8. doi: 10.1182/blood.V101.7.2483. Blood. 2003. PMID: 12642343 Free article.
Our study indicates that dietary factors are centrally important in the control of tHcy levels in young adults with additional, but somewhat weaker, genetic effects. These data underscore the potential benefits that may be gained by improving the dietary status of young …
Our study indicates that dietary factors are centrally important in the control of tHcy levels in young adults with additional, but s …
Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia.
Brown KS, Kluijtmans LA, Young IS, Woodside J, Yarnell JW, McMaster D, Murray L, Evans AE, Boreham CA, McNulty H, Strain JJ, Mitchell LE, Whitehead AS. Brown KS, et al. Among authors: young is. Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1014-20. doi: 10.1161/01.ATV.0000071348.70527.F4. Epub 2003 Apr 10. Arterioscler Thromb Vasc Biol. 2003. PMID: 12689917
The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects.
Brown KS, Kluijtmans LA, Young IS, McNulty H, Mitchell LE, Yarnell JW, Woodside JV, Boreham CA, McMaster D, Murray L, Strain JJ, Whitehead AS. Brown KS, et al. Among authors: young is. Hum Genet. 2004 Jan;114(2):182-5. doi: 10.1007/s00439-003-1039-9. Epub 2003 Oct 25. Hum Genet. 2004. PMID: 14586640
The TYMS gene has a tandem repeat polymorphism (two repeats or three repeats, designated 2R or 3R, respectively), which may also affect homocysteine concentrations. The 3R allele is subject to increased translational efficiency in vitro and the 3R3R genotype is asso …
The TYMS gene has a tandem repeat polymorphism (two repeats or three repeats, designated 2R or 3R, respectively), which may also affect homo …
The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.
Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JW, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Mitchell LE, Whitehead AS. Brown KS, et al. Among authors: young is. Atherosclerosis. 2004 Jun;174(2):315-22. doi: 10.1016/j.atherosclerosis.2004.01.023. Atherosclerosis. 2004. PMID: 15136061 Clinical Trial.
We tested this hypothesis in a healthy young adult population for which MTHFR C677T genotypes and tHcy concentrations were previously reported. ...We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate …
We tested this hypothesis in a healthy young adult population for which MTHFR C677T genotypes and tHcy concentrations were previously …
Evidence for sex differences in the determinants of homocysteine concentrations.
Stanisławska-Sachadyn A, Woodside JV, Brown KS, Young IS, Murray L, McNulty H, Strain JJ, Boreham CA, Scott JM, Whitehead AS, Mitchell LE. Stanisławska-Sachadyn A, et al. Among authors: young is. Mol Genet Metab. 2008 Apr;93(4):355-62. doi: 10.1016/j.ymgme.2007.11.004. Epub 2008 Jan 3. Mol Genet Metab. 2008. PMID: 18180190 Free article.
A high homocysteine phenotype, often accompanied by low folate, is associated with several pathologies including cardiovascular disease and birth defects. ...The present analyses were undertaken to identify the determinants of homocysteine concentrations in young me …
A high homocysteine phenotype, often accompanied by low folate, is associated with several pathologies including cardiovascular disea …
An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.
Stanisławska-Sachadyn A, Brown KS, Mitchell LE, Woodside JV, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. Stanisławska-Sachadyn A, et al. Among authors: young is. Hum Genet. 2008 Apr;123(3):289-95. doi: 10.1007/s00439-008-0475-y. Epub 2008 Feb 5. Hum Genet. 2008. PMID: 18247058
A low serum folate and high homocysteine phenotype is associated with an increased risk of neural tube defects (NTDs), cardiovascular diseases and other pathologies. ...The impact of the dihydrofolate reductase (DHFR) c.86 + 60_78 insertion/deletion (ins/del) polymorphism …
A low serum folate and high homocysteine phenotype is associated with an increased risk of neural tube defects (NTDs), cardiovascular …
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS. Hammons AL, et al. Among authors: young is. Clin Immunol. 2009 Oct;133(1):132-7. doi: 10.1016/j.clim.2009.06.008. Epub 2009 Jul 21. Clin Immunol. 2009. PMID: 19625220 Free PMC article.
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate status, is a known risk …
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerot …
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.
Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS. Stanisławska-Sachadyn A, et al. Among authors: young is. Ann Hum Genet. 2009 Sep;73(Pt 5):484-91. doi: 10.1111/j.1469-1809.2009.00529.x. Epub 2009 Jul 28. Ann Hum Genet. 2009. PMID: 19650776 Free PMC article.
Low folate status may be a consequence of suboptimal intake, transport or cellular utilization of folate and, together with elevated homocysteine, is a recognized risk factor or marker for several human pathologies. As folate transport across cell membranes is media …
Low folate status may be a consequence of suboptimal intake, transport or cellular utilization of folate and, together with elevated homocys …
484 results