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Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.
J Med Chem. 2006 Feb 23;49(4):1379-87. doi: 10.1021/jm050943c.
J Med Chem. 2006.
PMID: 16480273
Free PMC article.
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.
Tie Y, Boross PI, Wang YF, Gaddis L, Hussain AK, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT.
Tie Y, et al. Among authors: leshchenko s.
J Mol Biol. 2004 Apr 23;338(2):341-52. doi: 10.1016/j.jmb.2004.02.052.
J Mol Biol. 2004.
PMID: 15066436
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Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.
Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H.
Ghosh AK, et al. Among authors: leshchenko s.
J Med Chem. 2006 Aug 24;49(17):5252-61. doi: 10.1021/jm060561m.
J Med Chem. 2006.
PMID: 16913714
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Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.
Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT.
Kovalevsky AY, et al. Among authors: leshchenko s.
J Mol Biol. 2006 Oct 13;363(1):161-73. doi: 10.1016/j.jmb.2006.08.007. Epub 2006 Aug 4.
J Mol Biol. 2006.
PMID: 16962136
Free PMC article.
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Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).
Ghosh AK, Leshchenko S, Noetzel M.
Ghosh AK, et al. Among authors: leshchenko s.
J Org Chem. 2004 Nov 12;69(23):7822-9. doi: 10.1021/jo049156y.
J Org Chem. 2004.
PMID: 15527257
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Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H.
Ghosh AK, et al. Among authors: leshchenko s.
J Med Chem. 2005 May 19;48(10):3576-85. doi: 10.1021/jm050019i.
J Med Chem. 2005.
PMID: 15887965
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Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.
Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H.
Ghosh AK, et al. Among authors: leshchenko s.
Bioorg Med Chem Lett. 2006 Apr 1;16(7):1869-73. doi: 10.1016/j.bmcl.2006.01.011. Epub 2006 Feb 15.
Bioorg Med Chem Lett. 2006.
PMID: 16480871
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[Omega-3 polyunsaturated fatty acids in the correction of hemodynamic disorders in patients with chronic cor pulmonale].
Leshchenko SI.
Leshchenko SI.
Lik Sprava. 1999 Sep;(6):119-22.
Lik Sprava. 1999.
PMID: 10626463
Clinical Trial.
Ukrainian.
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