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Page 1
A structure-based approach to retinoid X receptor-alpha inhibition.
Stebbins JL, Jung D, Leone M, Zhang XK, Pellecchia M. Stebbins JL, et al. Among authors: pellecchia m. J Biol Chem. 2006 Jun 16;281(24):16643-8. doi: 10.1074/jbc.M600318200. Epub 2006 Apr 10. J Biol Chem. 2006. PMID: 16606625 Free article.
Structure-based discovery of a new class of Bcl-xL antagonists.
Rega MF, Leone M, Jung D, Cotton NJ, Stebbins JL, Pellecchia M. Rega MF, et al. Among authors: pellecchia m. Bioorg Chem. 2007 Aug;35(4):344-53. doi: 10.1016/j.bioorg.2007.03.001. Epub 2007 May 21. Bioorg Chem. 2007. PMID: 17512966 Free PMC article.
Identification of a novel Mcl-1 protein binding motif.
Placzek WJ, Sturlese M, Wu B, Cellitti JF, Wei J, Pellecchia M. Placzek WJ, et al. Among authors: pellecchia m. J Biol Chem. 2011 Nov 18;286(46):39829-35. doi: 10.1074/jbc.M111.305326. Epub 2011 Sep 27. J Biol Chem. 2011. PMID: 21953453 Free PMC article.
Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.
Hedvat M, Emdad L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelman TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, Wu B, Stebbins JL, Diaz PW, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Hedvat M, et al. Among authors: pellecchia m. Anticancer Agents Med Chem. 2012 Nov;12(9):1143-55. doi: 10.2174/187152012803529709. Anticancer Agents Med Chem. 2012. PMID: 22931411 Free PMC article. Review.
Structure-based design of covalent Siah inhibitors.
Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M. Stebbins JL, et al. Among authors: pellecchia m. Chem Biol. 2013 Aug 22;20(8):973-82. doi: 10.1016/j.chembiol.2013.06.008. Epub 2013 Jul 25. Chem Biol. 2013. PMID: 23891150 Free PMC article.
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY. Shiryaev SA, et al. Among authors: pellecchia m. J Biol Chem. 2007 Jul 20;282(29):20847-53. doi: 10.1074/jbc.M703847200. Epub 2007 May 30. J Biol Chem. 2007. PMID: 17537721 Free article.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Stebbins JL, et al. Among authors: pellecchia m. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15. Proc Natl Acad Sci U S A. 2008. PMID: 18922779 Free PMC article.
461 results